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Article

Association between long interspersed nuclear element-1 methylation levels and relapse in Wilms tumors

1 Dec 2017

Abstract excerpt

Wilms tumor (WT) is a curable pediatric renal malignancy, but there is a need for new molecular biomarkers to improve relapse risk-directed therapy. Somatic alterations occur at relatively low frequencies whereas epigenetic changes at 11p15 are the most common aberration. We analyzed long interspersed element-1 (LINE-1) methylation levels in the blastemal component of WT and normal kidney samples to explore their...

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PMID: 29255497
DOI: 10.1186/s13148-017-0431-6

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