Article
Clinically relevant subsets identified by gene expression patterns support a revised ontogenic model of Wilms tumor: a Children's Oncology Group Study.
Neoplasia (New York, N.Y.) - 1 Aug 2012
Gadd Samantha, Huff Vicki, Huang Chiang-Ching, Ruteshouser E Cristy, Dome Jeffrey S, Grundy Paul E, Breslow Norman, Jennings Lawrence, Green Daniel M, Beckwith J Bruce, Perlman Elizabeth J
Abstract excerpt
Wilms tumors (WT) have provided broad insights into the interface between development and tumorigenesis. Further understanding is confounded by their genetic, histologic, and clinical heterogeneity, the basis of which remains largely unknown. We evaluated 224 WT for global gene expression patterns; WT1, CTNNB1, and WTX mutation; and 11p15 copy number and methylation patterns. Five subsets were identified showing...
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