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Article

Wilms tumor chromatin profiles highlight stem cell properties and a renal developmental network.

Cell stem cell - 4 Jun 2010

Aiden Aviva Presser, Rivera Miguel N, Rheinbay Esther, Ku Manching, Coffman Erik J, Truong Thanh T, Vargas Sara O, Lander Eric S, Haber Daniel A, Bernstein Bradley E

Abstract excerpt

Wilms tumor is the most common pediatric kidney cancer. To identify transcriptional and epigenetic mechanisms that drive this disease, we compared genome-wide chromatin profiles of Wilms tumors, embryonic stem cells (ESCs), and normal kidney. Wilms tumors prominently exhibit large active chromatin domains previously observed in ESCs. In the cancer, these domains frequently correspond to genes that are critical...

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Identifiers

PMID: 20569696
DOI: 10.1016/j.stem.2010.03.016
PMCID: PMC2897075

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