Article
Mst1 directs Myosin IIa partitioning of low and higher affinity integrins during T cell migration.
PloS one - 1 Jan 2014
Xu Xiaolu, Jaeger Emily R, Wang Xinxin, Lagler-Ferrez Erica, Batalov Serge, Mathis Nancy L, Wiltshire Tim, Walker John R, Cooke Michael P, Sauer Karsten, Huang Yina H
Abstract excerpt
Chemokines promote T cell migration by transmitting signals that induce T cell polarization and integrin activation and adhesion. Mst1 kinase is a key signal mediator required for both of these processes; however, its molecular mechanism remains unclear. Here, we present a mouse model in which Mst1 function is disrupted by a hypomorphic mutation. Microscopic analysis of Mst1-deficient CD4 T cells revealed a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.