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Article

The mutational spectrum of Lynch syndrome in cyprus.

PloS one - 1 Jan 2014

Loizidou Maria A, Neophytou Ioanna, Papamichael Demetris, Kountourakis Panteleimon, Vassiliou Vassilios, Marcou Yiola, Kakouri Eleni, Ioannidis Georgios, Philippou Chrystalla, Spanou Elena, Tanteles George A, Anastasiadou Violetta, Hadjisavvas Andreas, Kyriacou Kyriacos

Abstract excerpt

Lynch syndrome is the most common form of hereditary colorectal cancer and is caused by germline mutations in the mismatch repair (MMR) genes MLH1, MSH2, MSH6 and PMS2. Mutation carriers have an increased lifetime risk of developing colorectal cancer as well as other extracolonic tumours. The aim of the current study was to evaluate the frequency and distribution of mutations in the MLH1, MSH2 and MSH6 genes...

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Source

Open in PubMed Open full text

Identifiers

PMID: 25133505
DOI: 10.1371/journal.pone.0105501
PMCID: PMC4136928

Genes

MLH1
MSH2
MSH6
PMS2
EPCAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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The mutational spectrum of Lynch syndrome in cyprus.PMID 25133505Read ↗

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