Article
First description of mutational analysis of MLH1, MSH2 and MSH6 in Algerian families with suspected Lynch syndrome.
Familial cancer - 1 Jan 2017
Ziada-Bouchaar H, Sifi K, Filali T, Hammada T, Satta D, Abadi N
Abstract excerpt
Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominant disorder characterized by the early onset of colorectal cancer (CRC) linked to germline defects in Mismatch Repair (MMR) genes. We present here, the first molecular study of the correlation between CRC and mutations occurring in these genes performed in twenty-one unrelated Algerian families. The presence of germline mutations in MMR...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.