Article
The variable phenotype and low-risk nature of RAS-positive thyroid nodules.
BMC medicine - 7 Aug 2015
Medici Marco, Kwong Norra, Angell Trevor E, Marqusee Ellen, Kim Matthew I, Frates Mary C, Benson Carol B, Cibas Edmund S, Barletta Justine A, Krane Jeffrey F, Ruan Daniel T, Cho Nancy L, Gawande Atul A, Moore Francis D, Alexander Erik K
Abstract excerpt
BACKGROUND: Oncogenic mutations are common in thyroid cancers. While the frequently detected RAS-oncogene mutations have been studied for diagnostic use in cytologically indeterminate thyroid nodules, no investigation has studied such mutations in an unselected population of thyroid nodules. No long-term study of RAS-positive thyroid nodules has been performed. METHODS: We performed a prospective, blinded cohort...
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