Article
Malignancy Risk, Molecular Mutations, and Surgical Outcomes of Thyroid Nodules Classified as Atypia of Undetermined Significance in the Bethesda System: A Comprehensive Analysis.
Cytopathology : official journal of the British Society for Clinical Cytology - 1 Jan 2026
Bourque Caroline, Savoia Gianluca, Noik Maxine, Florianova Livia, Bandargal Saruchi, da Silva Sabrina Daniela, Payne Richard, Pusztaszeri Marc Philippe
Abstract excerpt
OBJECTIVES: Thyroid nodules classified as atypia of undetermined significance (AUS) within the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) present a diagnostic challenge, with a risk of malignancy (ROM) of 5% to 50%. In 2017, TBSRTC introduced AUS subcategories to enhance ROM assessment. This study explores the correlation between AUS subclassification, molecular mutations, and surgical outcomes....
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