Article
Action of nitroheterocyclic drugs against Clostridium difficile.
International journal of antimicrobial agents - 1 Oct 2014
Kumar Manish, Adhikari Sudip, Hurdle Julian G
Abstract excerpt
The nitroheterocyclic classes of drugs have a long history of use in treating anaerobic infections, as exemplified by metronidazole as a first-line treatment for mild-to-moderate Clostridium difficile infection (CDI). Since direct comparisons of the three major classes of nitroheterocyclic drugs (i.e. nitroimidazole, nitazoxanide and nitrofurans) and nitrosating agents against C. difficile are under-examined, in...
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