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Article

Enzymes associated with reductive activation and action of nitazoxanide, nitrofurans, and metronidazole in Helicobacter pylori.

Antimicrobial agents and chemotherapy - 1 Jul 2002

Sisson Gary, Goodwin Avery, Raudonikiene Ausra, Hughes Nicky J, Mukhopadhyay Asish K, Berg Douglas E, Hoffman Paul S

Abstract excerpt

Nitazoxanide (NTZ) is a redox-active nitrothiazolyl-salicylamide prodrug that kills Helicobacter pylori and also many anaerobic bacterial, protozoan, and helminthic species. Here we describe development and use of a spectrophotometric assay, based on nitroreduction of NTZ at 412 nm, to identify H...

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Identifiers

PMID: 12069963
DOI: 10.1128/AAC.46.7.2116-2123.2002
PMCID: PMC127316

Genes

POR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12069963-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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