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Article

Functional analysis of the RdxA and RdxB nitroreductases of Campylobacter jejuni reveals that mutations in rdxA confer metronidazole resistance.

Journal of bacteriology - 1 Apr 2010

Ribardo Deborah A, Bingham-Ramos Lacey K, Hendrixson David R

Abstract excerpt

Campylobacter jejuni is a leading cause of gastroenteritis in humans and a commensal bacterium of the intestinal tracts of many wild and agriculturally significant animals. We identified and characterized a locus, which we annotated as rdxAB, encoding two nitroreductases. RdxA was found to be responsible for sensitivity to metronidazole (Mtz), a common therapeutic agent for another epsilonproteobacterium,...

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Identifiers

PMID: 20118248
DOI: 10.1128/JB.01638-09
PMCID: PMC2838047

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