Article
Mutation of the protein kinase I alpha leucine zipper domain produces hypertension and progressive left ventricular hypertrophy: a novel mouse model of age-dependent hypertensive heart disease.
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Nov 2013
Blanton Robert M, Takimoto Eiki, Aronovitz Mark, Thoonen Robrecht, Kass David A, Karas Richard H, Mendelsohn Michael E
Abstract excerpt
Hypertensive heart disease causes significant mortality in older patients, yet there is an incomplete understanding of molecular mechanisms that regulate age-dependent hypertensive left ventricular hypertrophy (LVH). Therefore, we tested the hypothesis that the cGMP-dependent protein kinase G I a...
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