Article

Essential Role of Protein Kinase R in the Pathogenesis of Pulmonary Veno-occlusive Disease

2025-04-23

Abstract excerpt

Pulmonary veno-occlusive disease (PVOD) is a rare and severe subtype of pulmonary arterial hypertension, marked by progressive remodeling of small pulmonary arteries and veins with no therapies. Using a mitomycin C (MMC)-induced rat model, we previously demonstrated that protein kinase R (PKR)-mediated integrated stress response (ISR) drives endothelial dysfunction and vascular remodeling. To determine if PKR is t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4a1672c1-f627-5a06-ab44-302c951b21c3
DOI: 10.1101/2025.04.18.649514

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Essential Role of Protein Kinase R in the Pathogenesis of Pulmonary Veno-occlusive DiseaseDOI 10.1101/2025.04.18.649514Read

Reversal of pulmonary veno-occlusive disease phenotypes by inhibition of the integrated stress responseSemantic proximity Read

Reversal of pulmonary veno-occlusive disease phenotypes by inhibition of the integrated stress response.Semantic proximity Read

Transcriptomic Signature of Right Ventricular Failure in Experimental Pulmonary Arterial Hypertension: Deep Sequencing Demonstrates Mitochondrial, Fibrotic, Inflammatory and Angiogenic AbnormalitiesSemantic proximity Read

Multimodality Molecular Profiling Nominates Targetable Mechanisms in Progressive RV DysfunctionSemantic proximity Read

Comparison of Human and Experimental Pulmonary Veno-Occlusive Disease.Semantic proximity Read

Interleukin-6 is critical in the development of <i>gcn2-</i> mutation associated pulmonary vascular disease in miceSemantic proximity Read

PINK1-mediated Mitophagy Contributes to Pulmonary Vascular Remodeling in Pulmonary HypertensionSemantic proximity Read

Histologic and Proteomic Remodeling of the Pulmonary Veins and Arteries in a Porcine Model of Chronic Pulmonary Venous HypertensionSemantic proximity Read

Anticipated Classes of New Medications and Molecular Targets for Pulmonary Arterial HypertensionSemantic proximity Read

PKG-1α leucine zipper domain defect increases pulmonary vascular tone: implications in hypoxic pulmonary hypertension.Semantic proximity Read

Gene expression profiling of common signal transduction pathways affected by rBMSCs/F92A-Cav1 in the lungs of rat with pulmonary arterial hypertension.Semantic proximity Read

PTBP1 Targets ILK to Regulate the Hypoxia-Induced Phenotypic Transformation of Pulmonary Artery Smooth Muscle Cells.Semantic proximity Read