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Article

Disruption of the potassium channel regulatory subunit KCNE2 causes iron-deficient anemia.

Experimental hematology - 1 Dec 2014

Salsbury Grace, Cambridge Emma L, McIntyre Zoe, Arends Mark J, Karp Natasha A, Isherwood Christopher, Shannon Carl, Hooks Yvette, Ramirez-Solis Ramiro, Adams David J, White Jacqueline K, Speak Anneliese O

Abstract excerpt

Iron homeostasis is a dynamic process that is tightly controlled to balance iron uptake, storage, and export. Reduction of dietary iron from the ferric to the ferrous form is required for uptake by solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 (Slc11a2) into the enterocytes. Both processes are proton dependent and have led to the suggestion of the importance of acidic gastric...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25127743
DOI: 10.1016/j.exphem.2014.07.269
PMCID: PMC4271779

Genes

KCNQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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