Article
Elevated serum gastrin levels in Jervell and Lange-Nielsen syndrome: a marker of severe KCNQ1 dysfunction?
Heart rhythm - 1 Apr 2011
Rice Kathryn S, Dickson Graeme, Lane Mark, Crawford Jackie, Chung Seo-Kyung, Rees Mark I, Shelling Andrew N, Love Donald R, Skinner Jonathan R
Abstract excerpt
BACKGROUND: The potassium channel I(Ks), which is encoded by the KCNQ1 gene, is expressed in organ systems including the inner ear, kidneys, lungs, intestine, and stomach in addition to the heart. Increasing evidence indicates that I(Ks) in the stomach plays an essential role in enabling gastric acid production. It is not known whether gastric acid production is disordered in patients with long QT type 1. Serum...
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