Article
Is the iron donor lipocalin 2 implicated in the pathophysiology of hereditary hemochromatosis?
Hepatology (Baltimore, Md.) - 1 Mar 2009
Huang Hua, Akira Shizuo, Santos Manuela M
Abstract excerpt
UNLABELLED: Under normal conditions, iron is taken up by the cells through the transferrin-mediated pathway. However, in hereditary hemochromatosis, a common iron-overloading disorder associated with mutations in the HFE gene, iron in plasma exceeds transferrin-binding capacity, and non-transferrin-bound iron (NTBI) appears in the circulation of patients with iron overload. NTBI can be taken up by hepatocytes...
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