Article
Disposal of iron by a mutant form of lipocalin 2.
Nature communications - 31 Oct 2016
Barasch Jonathan, Hollmen Maria, Deng Rong, Hod Eldad A, Rupert Peter B, Abergel Rebecca J, Allred Benjamin E, Xu Katherine, Darrah Shaun F, Tekabe Yared, Perlstein Alan, Wax Rebecca, Bruck Efrat, Stauber Jacob, Corbin Kaitlyn A, Buchen Charles, Slavkovich Vesna, Graziano Joseph, Spitalnik Steven L, Bao Guanhu, Strong Roland K, Qiu Andong
Abstract excerpt
Iron overload damages many organs. Unfortunately, therapeutic iron chelators also have undesired toxicity and may deliver iron to microbes. Here we show that a mutant form (K3Cys) of endogenous lipocalin 2 (LCN2) is filtered by the kidney but can bypass sites of megalin-dependent recapture, resulting in urinary excretion. Because K3Cys maintains recognition of its cognate ligand, the iron siderophore...
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