IFN-gamma and TNF associated with severe falciparum malaria infection in Saudi pregnant women.

doi:10.1186/1475-2875-13-314

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Article

IFN-gamma and TNF associated with severe falciparum malaria infection in Saudi pregnant women.

Malaria journal - 13 Aug 2014

Nasr Amre, Allam Gamal, Hamid Osama, Al-Ghamdi Abdelhamid

Abstract excerpt

BACKGROUND: Tumour necrosis factor (TNF) and interferon gamma (IFN-γ), encoded by TNF-836 C/A (rs 1800630) and IFN-γ -1616 C/T (rs2069705) genes, are key immunological mediators that are believed to both play protective and pathological roles in malaria. The aim of this study was to investigate the relationship between TNF-836 C/A and IFN-γ-1616 C/T polymorphism and susceptibility to severe malaria in pregnant...

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PMID: 25124540
DOI: 10.1186/1475-2875-13-314
PMCID: PMC4137072

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