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AAV-mediated rescue of Eps8 expression in vivo restores hair-cell function in a mouse model of recessive deafness

31 Jul 2022

Abstract excerpt

The transduction of acoustic information by hair cells depends upon mechanosensitive stereociliary bundles that project from their apical surface. Mutations or absence of the stereociliary protein EPS8 cause deafness in humans and mice, respectively. Eps8 knockout mice ( Eps8 −/− ) have hair cells with immature stereocilia and fail to become sensory receptors. Here, we show that exogenous delivery of Eps8 using...

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PMID: 36034774
DOI: 10.1016/j.omtm.2022.07.012

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