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Article

Disruption of the autism-related gene Pak1 causes stereocilia disorganization, hair cell loss, and deafness in mice

1 Apr 2021

Abstract excerpt

Several clinical studies have reported that hearing loss is correlated with autism in children. However, little is known about the underlying mechanism between hearing loss and autism. p21-activated kinases (PAKs) are a family of serine/threonine kinases that can be activated by multiple signaling molecules, particularly the Rho family of small GTPases. Previous studies have shown that Pak1 mutations are...

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Share to Calcium signaling and nucleotide metabolism
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PMID: 34049799
DOI: 10.1016/j.jgg.2021.03.010

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