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Article

Inherited variation in the ATP-binding cassette transporter ABCB1 and survival after chemotherapy for stage III-IV lung cancer.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Sept 2014

Weissfeld Joel L, Diergaarde Brenda, Nukui Tomoko, Buch Shama, Pennathur Arjun, Socinski Mark A, Siegfried Jill M, Romkes Marjorie

Abstract excerpt

BACKGROUND: The ATP-binding cassette transporter gene ABCB1 and the glutathione S-transferase gene GSTP1 code for a multidrug resistance protein and for a detoxifying phase II metabolic enzyme, respectively, with substrate specificities that include chemotherapy drugs often used to treat lung cancer. METHODS: We genotyped 11 ABCB1 and eight GSTP1 single nucleotide polymorphisms (SNPs) in 698 white lung cancer...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25122423
DOI: 10.1097/JTO.0000000000000262
PMCID: PMC4134100

Genes

ABCB1
GSTP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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