Article
Clinical Significance of ABCG2 Haplotype-tagging Single Nucleotide Polymorphisms in Patients With Unresectable Non-Small Cell Lung Cancer Treated With First-line Platinum-based Chemotherapy.
American journal of clinical oncology - 1 Jun 2015
Kim Seok-Hyun, Kim Moon Jin, Cho Yu Ji, Jeong Yi Yeong, Kim Ho-Cheol, Lee Jong Duk, Hwang Young Sil, Kim In-Suk, Lee Suee, Oh Sung Yong, Ling Hui, Lee Gyeong-Won
Abstract excerpt
OBJECTIVES: The ATP-binding cassette (ABC) ABCG2, involved in multidrug resistance (MDR) in cancer cells, plays an integral role in drug resistance. Single nucleotide polymorphisms (SNPs) have been identified in many MDR-associated ABC genes that seem to influence drug sensitivity/resistance thro...
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