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Article

Polymorphisms in ABCG2, ABCC3 and CNT1 genes and their possible impact on chemotherapy outcome of lung cancer patients.

International journal of cancer - 1 Apr 2009

Müller Phillip J, Dally Heike, Klappenecker Cornelia N, Edler Lutz, Jäger Birgit, Gerst Martina, Spiegelhalder Bertold, Tuengerthal Siegfried, Fischer Jürgen R, Drings Peter, Bartsch Helmut, Risch Angela

Abstract excerpt

The prognosis of lung cancer patients treated with chemotherapy is poor, motivating the search for predictive factors. Single nucleotide polymorphisms (SNPs) in membrane transporter genes could influence the pharmacokinetics of cytostatic drugs and therefore affect treatment outcome. We examined 6 SNPs with known or suspected phenotypic effect: ABCG2 G34A, C421A; ABCC3 C-211T, G3890A, C3942T and CNT1 G565A. For...

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Share to ATP Binding Cassette Transporter, Subfamily G, Member 2
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Source

Identifiers

PMID: 19107936
DOI: 10.1002/ijc.23956

Genes

ABCC3
ABCG2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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