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HCMV pUL135 Remodels the Actin Cytoskeleton to Impair Immune Recognition of Infected Cells

1 Aug 2014

Abstract excerpt

Immune evasion genes help human cytomegalovirus (HCMV) establish lifelong persistence. Without immune pressure, laboratory-adapted HCMV strains have undergone genetic alterations. Among these, the deletion of the UL/b' domain is associated with loss of virulence. In a screen of UL/b', we identified pUL135 as a protein responsible for the characteristic cytopathic effect of clinical HCMV strains that also...

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PMID: 25121749
DOI: 10.1016/j.chom.2014.07.005

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