Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HCMV-Encoded NK Modulators: Lessons From in vitro and in vivo Genetic Variation

1 Oct 2018

Abstract excerpt

Human cytomegalovirus (HCMV) is under constant selective pressure from the immune system in vivo. Study of HCMV genes that have been lost in the absence of, or genetically altered by, such selection can focus research towards findings of in vivo significance. We have been particularly interested in the most pronounced change in the highly passaged laboratory strains AD169 and Towne – the deletion of 13-15kb of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to Immune Cell Function and Interaction
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30327650
DOI: 10.3389/fimmu.2018.02214

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HCMV-Encoded NK Modulators: Lessons From in vitro and in vivo Genetic VariationPMID 30327650Read ↗

Spontaneous mutations in the human CMV HLA class I homologue UL18 affect its binding to the inhibitory receptor LIR‐1/ILT2/CD85jSemantic proximity Read ↗

The human cytomegalovirus protein UL147A downregulates the most prevalent MICA allele: MICA*008, to evade NK cell-mediated killingSemantic proximity Read ↗

Human Cytomegalovirus Encodes an MHC Class I-Like Molecule (UL142) That Functions to Inhibit NK Cell LysisSemantic proximity Read ↗

The structure of cytomegalovirus immune modulator UL141 highlights structural Ig-fold versatility for receptor binding.Semantic proximity Read ↗

Genetic Variability of Human Cytomegalovirus Clinical Isolates Correlates With Altered Expression of Natural Killer Cell-Activating Ligands and IFN-γ.Semantic proximity Read ↗

Diversity of NKG2C genotypes in a European population: Conserved and recombinant haplotypes in the coding, promoter, and 3'-untranslated regions.Semantic proximity Read ↗

NKG2D Ligand MICA Is Retained in the<i>cis</i>-Golgi Apparatus by Human Cytomegalovirus Protein UL142Semantic proximity Read ↗

Human Cytomegalovirus Glycoprotein UL141 Targets the TRAIL Death Receptors to Thwart Host Innate Antiviral DefensesSemantic proximity Read ↗

The Evolutionary Arms Race between Virus and NK Cells: Diversity Enables Population-Level Virus ControlSemantic proximity Read ↗

Downregulation of natural killer cell-activating ligand CD155 by human cytomegalovirus UL141.Semantic proximity Read ↗

The human cytomegalovirus protein UL147A downregulates the most prevalent MICA allele: MICA*008, to evade NK cell-mediated killing.Semantic proximity Read ↗

Two Novel Human Cytomegalovirus NK Cell Evasion Functions Target MICA for Lysosomal DegradationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.