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Host IQGAP1 and Ebola Virus VP40 Interactions Facilitate Virus-Like Particle Egress

2 May 2013

Abstract excerpt

We have identified host IQGAP1 as an interacting partner for Ebola virus (EBOV) VP40, and its expression is required for EBOV VP40 virus-like particle (VLP) budding. IQGAP1 is involved in actin cytoskeletal remodeling during cell migration and formation of filopodia. The physical interaction and the functional requirement for IQGAP1 in EBOV VP40 VLP egress link virus budding to the cytoskeletal remodeling...

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PMID: 23637409
DOI: 10.1128/jvi.00470-13

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