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Article

Functional balance between the hemagglutinin and neuraminidase of influenza A(H1N1)pdm09 HA D222 variants.

PloS one - 1 Jan 2014

Casalegno Jean-Sébastien, Ferraris Olivier, Escuret Vanessa, Bouscambert Maude, Bergeron Corinne, Linès Laetitia, Excoffier Thierry, Valette Martine, Frobert Emilie, Pillet Sylvie, Pozzetto Bruno, Lina Bruno, Ottmann Michèle

Abstract excerpt

D222G/N substitutions in A(H1N1)pdm09 hemagglutinin may be associated with increased binding of viruses causing low respiratory tract infections and human pathogenesis. We assessed the impact of such substitutions on the balance between hemagglutinin binding and neuraminidase cleavage, viral growth and in vivo virulence.Seven viruses with differing polymorphisms at codon 222 (2 with D, 3 G, 1 N and 1 E) were...

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Identifiers

PMID: 25119465
DOI: 10.1371/journal.pone.0104009
PMCID: PMC4131921

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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