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Structural and functional characterization of avian influenza H9N2 virus neuraminidase with a combination of five novel mutations.

Archives of biochemistry and biophysics - 1 Jul 2024

Tare Deeksha S, Pawar Shailesh D, Shil Pratip, Atre Nitin M

Abstract excerpt

The influenza virus neuraminidase (NA) protein is responsible for actively cleaving the sialic acid (SA) bound to the viral hemagglutinin. In the present study, we identified a combination of five novel amino acid substitutions in the NA, conferring increased substrate binding and altered surface characteristics to a low pathogenic avian influenza (LPAI) H9N2 virus strain. The H9N2 strain reported from India,...

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PMID: 38750923
DOI: 10.1016/j.abb.2024.110041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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