Article
Effect of D222G mutation in the hemagglutinin protein on receptor binding, pathogenesis and transmissibility of the 2009 pandemic H1N1 influenza virus.
PloS one - 1 Jan 2011
Belser Jessica A, Jayaraman Akila, Raman Rahul, Pappas Claudia, Zeng Hui, Cox Nancy J, Katz Jacqueline M, Sasisekharan Ram, Tumpey Terrence M
Abstract excerpt
Influenza viruses isolated during the 2009 H1N1 pandemic generally lack known molecular determinants of virulence associated with previous pandemic and highly pathogenic avian influenza viruses. The frequency of the amino acid substitution D222G in the hemagglutinin (HA) of 2009 H1N1 viruses isolated from severe but not mild human cases represents the first molecular marker associated with enhanced disease. To...
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