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Article

Characterization of 2 influenza A(H3N2) clinical isolates with reduced susceptibility to neuraminidase inhibitors due to mutations in the hemagglutinin gene.

The Journal of infectious diseases - 15 Oct 2002

Abed Yacine, Bourgault Anne-Marie, Fenton Robert J, Morley Peter J, Gower David, Owens Ian J, Tisdale Margaret, Boivin Guy

Abstract excerpt

Previous studies have shown that amino acid changes in the hemagglutinin (HA) gene of influenza viruses may result in decreased susceptibility to neuraminidase inhibitors (NAIs) in vitro. However, the emergence and characteristics of such HA variants in the clinical setting remain poorly studied. Herein, we report 2 influenza A(H3N2) isolates, from untreated patients, harboring an Arg229-->Ile substitution in the...

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PMID: 12355356
DOI: 10.1086/344237

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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