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Article

The 2009 pandemic H1N1 D222G hemagglutinin mutation alters receptor specificity and increases virulence in mice but not in ferrets.

The Journal of infectious diseases - 1 Oct 2011

Abed Yacine, Pizzorno Andres, Hamelin Marie-Eve, Leung Anders, Joubert Philippe, Couture Christian, Kobasa Darwyn, Boivin Guy

Abstract excerpt

BACKGROUND: The D222G (H1 numbering) hemagglutinin (HA) mutation within the receptor-binding site was detected with higher frequencies in severe cases of 2009 pandemic H1N1 (pH1N1) infections. We investigated the impact of this mutation in vitro and in animal models using recombinant pH1N1 viruse...

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Identifiers

PMID: 21881115
DOI: 10.1093/infdis/jir483

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21881115-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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