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Article

Engineering unnatural nucleotide specificity for Rous sarcoma virus tyrosine kinase to uniquely label its direct substrates.

Proceedings of the National Academy of Sciences of the United States of America - 15 Apr 1997

Shah K, Liu Y, Deirmengian C, Shokat K M

Abstract excerpt

Protein phosphorylation plays a central role in controlling many diverse signal transduction pathways in all cells. Novel protein kinases are identified at a rapid rate using homology cloning methods and genetic screens or selections; however identification of the direct substrates of kinases has proven elusive to genetic methods because of the tremendous redundancy and overlapping of substrate specificities...

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Identifiers

PMID: 9108016
DOI: 10.1073/pnas.94.8.3565
PMCID: PMC20479

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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