Article
Identification of 33 candidate oncogenes by screening for base-specific mutations.
British journal of cancer - 14 Oct 2014
Tuupanen S, Hänninen U A, Kondelin J, von Nandelstadh P, Cajuso T, Gylfe A E, Katainen R, Tanskanen T, Ristolainen H, Böhm J, Mecklin J-P, Järvinen H, Renkonen-Sinisalo L, Andersen C L, Taipale M, Taipale J, Vahteristo P, Lehti K, Pitkänen E, Aaltonen L A
Abstract excerpt
BACKGROUND: Genes with recurrent codon-specific somatic mutations are likely drivers of tumorigenesis and potential therapeutic targets. Hypermutable cancers may represent a sensitive system for generation and selection of oncogenic mutations. METHODS: We utilised exome-sequencing data on 25 sporadic microsatellite-instable (MSI) colorectal cancers (CRCs) and searched for base-specific somatic mutation hotspots....
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