The genomic landscape of oesophagogastric junctional adenocarcinoma.

doi:10.1002/path.4247

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Article

The genomic landscape of oesophagogastric junctional adenocarcinoma.

The Journal of pathology - 1 Nov 2013

Chong Irene Y, Cunningham David, Barber Louise J, Campbell James, Chen Lina, Kozarewa Iwanka, Fenwick Kerry, Assiotis Ioannis, Guettler Sebastian, Garcia-Murillas Isaac, Awan Saima, Lambros Maryou, Starling Naureen, Wotherspoon Andrew, Stamp Gordon, Gonzalez-de-Castro David, Benson Martin, Chau Ian, Hulkki Sanna, Nohadani Mahrokh, Eltahir Zakaria, Lemnrau Alina, Orr Nicholas, Rao Sheela, Lord Christopher J, Ashworth Alan

Abstract excerpt

The incidence of oesophagogastric junctional (OGJ) adenocarcinoma is rising rapidly in western countries, in contrast to the declining frequency of distal gastric carcinoma. Treatment options for adenocarcinomas involving the oesophagogastric junction are limited and the overall prognosis is extremely poor. To determine the genomic landscape of OGJ adenocarcinoma, exomes of eight tumours and matched germline DNA...

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PMID: 24308032
DOI: 10.1002/path.4247

Genes

ESRRB
FGFR4
HGF

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