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Article

Nuclear and cytoplasmic p53 suppress cell invasion by inhibiting respiratory complex-I activity via Bcl-2 family proteins.

Oncotarget - 30 Sept 2014

Kim Eun Mi, Park Jong Kuk, Hwang Sang-Gu, Kim Wun-Jae, Liu Zheng-Gang, Kang Sang Won, Um Hong-Duck

Abstract excerpt

Although the p53 tumor suppressor/transcription factor often accumulates in the cytoplasm of healthy cells, limited information is available on the cytoplasmic function of p53. Here, we show that cytoplasmic p53 suppresses cell invasion by reducing mitochondrial reactive oxygen species (ROS) levels. Analysis revealed that this function is mediated by Bcl-2 family proteins: Cytoplasmic p53 binds Bcl-w, liberating...

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Identifiers

PMID: 25115399
DOI: 10.18632/oncotarget.2320
PMCID: PMC4226696

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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