Article
UDP-N-acetylmuramic acid l-alanine ligase (MurC) inhibition in a tolC mutant Escherichia coli strain leads to cell death.
Antimicrobial agents and chemotherapy - 1 Oct 2014
Humnabadkar Vaishali, Prabhakar K R, Narayan Ashwini, Sharma Sreevalli, Guptha Supreeth, Manjrekar Praveena, Chinnapattu Murugan, Ramachandran Vasanthi, Hameed Shahul P, Ravishankar Sudha, Chatterji Monalisa
Abstract excerpt
The Mur ligases play an essential role in the biosynthesis of bacterial peptidoglycan and hence are attractive antibacterial targets. A screen of the AstraZeneca compound library led to the identification of compound A, a pyrazolopyrimidine, as a potent inhibitor of Escherichia coli and Pseudomonas aeruginosa MurC. However, cellular activity against E. coli or P. aeruginosa was not observed. Compound A was active...
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