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Article

Isolation of temperature-sensitive mutations in murC of Staphylococcus aureus.

FEMS microbiology letters - 1 Sept 2007

Ishibashi Mihoko, Kurokawa Kenji, Nishida Satoshi, Ueno Kohji, Matsuo Miki, Sekimizu Kazuhisa

Abstract excerpt

Enzymes in the bacterial peptidoglycan biosynthesis pathway are important targets for novel antibiotics. Of 750 temperature-sensitive (TS) mutants of Gram-positive Staphylococcus aureus, six were complemented by the murC gene, which encodes the UDP-N-acetylmuramic acid:l-alanine ligase. Each mutation resulted in a single amino acid substitution and, in all cases, the TS phenotype was suppressed by high osmotic...

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PMID: 17608695
DOI: 10.1111/j.1574-6968.2007.00829.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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