Article
Bayesian predictive model to assess BRCA2 mutational status according to clinical history: Early onset, metastatic phenotype or family history of breast/ovary cancer.
The Prostate - 1 May 2021
Leon Priscilla, Cancel-Tassin Geraldine, Bourdon Violaine, Buecher Bruno, Oudard Stephane, Brureau Laurent, Jouffe Lionel, Blanchet Pascal, Stoppa-Lyonnet Dominique, Coulet Florence, Sobol Hagay, Cussenot Olivier
Abstract excerpt
BACKGROUND: Mutations of the BRCA2 gene are the most frequent alterations found in germline DNA from men with prostate cancer (PrCa), but clinical parameters that could better orientate for BRCA2 mutation screening need to be established. METHODS: Germline DNA from 325 PrCa patients (median age at diagnosis: 57 years old) was screened for BRCA2 mutation. The mutation frequency was compared between three...
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