Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Germline BRCA mutation in male carriers-ripe for precision oncology?

Prostate cancer and prostatic diseases - 1 Apr 2018

Leão Ricardo Romão Nazário, Price Aryeh Joshua, James Hamilton Robert

Abstract excerpt

BACKGROUND: Prostate cancer (PC) is one of the known heritable cancers with individual variations attributed to genetic factors. BRCA1 and BRCA2 are tumour suppressor genes with crucial roles in repairing DNA and thereby maintaining genomic integrity. Germline BRCA mutations predispose to multiple familial tumour types including PC. METHODS: We performed a Pubmed database search along with review of reference...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BRCA1 Protein
Share to BRCA2 Protein
Share to Early Detection of Cancer

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Germ-Line Mutation

Share to Precision Medicine

Share to Prognosis

Share to Prostatic Neoplasms

Source

Identifiers

PMID: 29242595
DOI: 10.1038/s41391-017-0018-5

Genes

PC
BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Germline BRCA mutation in male carriers-ripe for precision oncology?PMID 29242595Read ↗

Review on the Role of BRCA Mutations in Genomic Screening and Risk Stratification of Prostate Cancer.Semantic proximity Read ↗

BRCA Germline Mutations in Prostate Cancer: The Future Is TailoredSemantic proximity Read ↗

Hereditary prostate cancer - Primetime for genetic testing?Semantic proximity Read ↗

The relevance of BRCA genetics to prostate cancer pathogenesis and treatment.Semantic proximity Read ↗

BRCA2 gene mutation and prostate cancer risk. Comprehensive review and update.Semantic proximity Read ↗

Germline genetics of prostate cancer.Semantic proximity Read ↗

Hereditary Prostate Cancer: Genes Related, Target Therapy and PreventionSemantic proximity Read ↗

Prostate Cancer Germline Variations and Implications for Screening and Treatment.Semantic proximity Read ↗

Prostate cancer genotyping for risk stratification and precision treatmentSemantic proximity Read ↗

Increased risk of male cancer and identification of a potential prostate cancer cluster region in BRCA2.Semantic proximity Read ↗

BRCA2 mutations should be screened early and routinely as markers of poor prognosis: evidence from 8,988 patients with prostate cancerSemantic proximity Read ↗

BRCA1 and BRCA2 mutations testing in prostate cancer: Detection in formalin fixed paraffin embedded (FFPE) and blood samplesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.