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Germline BRCA mutation in male carriers-ripe for precision oncology?

Prostate cancer and prostatic diseases - 1 Apr 2018

Leão Ricardo Romão Nazário, Price Aryeh Joshua, James Hamilton Robert

Abstract excerpt

BACKGROUND: Prostate cancer (PC) is one of the known heritable cancers with individual variations attributed to genetic factors. BRCA1 and BRCA2 are tumour suppressor genes with crucial roles in repairing DNA and thereby maintaining genomic integrity. Germline BRCA mutations predispose to multiple familial tumour types including PC. METHODS: We performed a Pubmed database search along with review of reference...

Topics

BRCA1 Protein
BRCA2 Protein
Early Detection of Cancer
Genetic Predisposition to Disease
Germ-Line Mutation
Humans
Male
Precision Medicine
Prognosis
Prostatic Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29242595
DOI: 10.1038/s41391-017-0018-5

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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