Article

High-Grade Prostate Adenocarcinoma in a BRCA2 Germline Mutation Carrier: Precision Oncology and Familial Cascade Testing: a case report

2025-12-22

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> : Germline mutations in BRCA2 are strongly associated with young age and dangerous prostate cancer due to the lack of homologous recombination (HRD), suggesting a window for targeted therapy and emphasizing the importance of family-oriented genetic screening. <bold>Case Presentation:</bold> The patient was of Iranian origin. A 43-year-old man presented with...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 28e24ea3-fd10-5e79-aac9-5ea51b5aabd5
DOI: 10.21203/rs.3.rs-7338087/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

High-Grade Prostate Adenocarcinoma in a BRCA2 Germline Mutation Carrier: Precision Oncology and Familial Cascade Testing: a case reportDOI 10.21203/rs.3.rs-7338087/v1Read

Prostate Cancer in a Patient with a Family History of BRCA Mutation: a Case Report and Literature Review.Semantic proximity Read

BRCA Germline Mutations in Prostate Cancer: The Future Is TailoredSemantic proximity Read

BRCA2 gene mutation and prostate cancer risk. Comprehensive review and update.Semantic proximity Read

Germline genetics of prostate cancer.Semantic proximity Read

Review on the Role of BRCA Mutations in Genomic Screening and Risk Stratification of Prostate Cancer.Semantic proximity Read

Clinical implications of homologous recombination repair mutations in prostate cancer.Semantic proximity Read

Germline BRCA mutation in male carriers-ripe for precision oncology?Semantic proximity Read

Prostate Cancer Screening in a New Era of Genetics.Semantic proximity Read

Hereditary prostate cancer - Primetime for genetic testing?Semantic proximity Read

Prostate cancer: What is the real IMPACT of BRCA1/BRCA2 mutation?Semantic proximity Read

Commentary on "Inherited DNA-repair gene mutations in men with metastatic prostate cancer". Pritchard CC, Mateo J, Walsh MF, De Sarkar N, Abida W, Beltran H, Garofalo A, Gulati R, Carreira S, Eeles R, Elemento O, Rubin MA, Robinson D, Lonigro R, Hussain M, Chinnaiyan A, Vinson J, Filipenko J, Garraway L, Taplin ME, AlDubayan S, Han GC, Beightol M, Morrissey C, Nghiem B, Cheng HH, Montgomery B, Walsh T, Casadei S, Berger M, Zhang L, Zehir A, Vijai J, Scher HI, Sawyers C, Schultz N, Kantoff PW, S…Semantic proximity Read

BRCA2 mutations should be screened early and routinely as markers of poor prognosis: evidence from 8,988 patients with prostate cancerSemantic proximity Read