Prostate Cancer Risk by BRCA2 Genomic Regions.

doi:10.1016/j.eururo.2020.05.005

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Article

Prostate Cancer Risk by BRCA2 Genomic Regions.

European urology - 1 Oct 2020

Nyberg Tommy, Frost Debra, Barrowdale Daniel, Evans D Gareth, Bancroft Elizabeth, Adlard Julian, Ahmed Munaza, Barwell Julian, Brady Angela F, Brewer Carole, Cook Jackie, Davidson Rosemarie, Donaldson Alan, Eason Jacqueline, Gregory Helen, Henderson Alex, Izatt Louise, Kennedy M John, Miller Claire, Morrison Patrick J, Murray Alex, Ong Kai-Ren, Porteous Mary, Pottinger Caroline, Rogers Mark T, Side Lucy, Snape Katie, Tripathi Vishakha, Walker Lisa, Tischkowitz Marc, Eeles Rosalind, Easton Douglas F, Antoniou Antonis C

Abstract excerpt

A BRCA2 prostate cancer cluster region (PCCR) was recently proposed (c.7914 to 3') wherein pathogenic variants (PVs) are associated with higher prostate cancer (PCa) risk than PVs elsewhere in the BRCA2 gene. Using a prospective cohort study of 447 male BRCA2 PV carriers recruited in the UK and Ireland from 1998 to 2016, we estimated standardised incidence ratios (SIRs) compared with population incidences and...

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Identifiers

PMID: 32532514
DOI: 10.1016/j.eururo.2020.05.005
PMCID: PMC7532700

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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