Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of BRCA1 and BRCA2 in prostate cancer.

Asian journal of andrology - 1 May 2012

Castro Elena, Eeles Rosalind

Abstract excerpt

One of the strongest risk factors for prostate cancer is a family history of the disease. Germline mutations in the breast cancer predisposition gene 2 (BRCA2) are the genetic events known to date that confer the highest risk of prostate cancer (8.6-fold in men ≤65 years). Although the role of BRCA2 and BRCA1 in prostate tumorigenesis remains unrevealed, deleterious mutations in both genes have been associated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers, Tumor
Share to BRCA2 Protein
Share to BRCA2 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Germ-Line Mutation

Share to Prostatic Neoplasms

Share to Risk Factors

Share to Ubiquitin-Protein Ligases

Source

Open in PubMed Open full text

Identifiers

PMID: 22522501
DOI: 10.1038/aja.2011.150
PMCID: PMC3720154

Genes

BRCA2
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of BRCA1 and BRCA2 in prostate cancer.PMID 22522501Read ↗

The role of the BRCA2 gene in susceptibility to prostate cancer revisited.Semantic proximity Read ↗

The relevance of BRCA genetics to prostate cancer pathogenesis and treatment.Semantic proximity Read ↗

BRCA2 gene mutation and prostate cancer risk. Comprehensive review and update.Semantic proximity Read ↗

Prostate cancer risk, screening and management in patients with germline BRCA1/2 mutations.Semantic proximity Read ↗

Pathogenic BRCA Variants as Biomarkers for Risk in Prostate CancerSemantic proximity Read ↗

Review on the Role of BRCA Mutations in Genomic Screening and Risk Stratification of Prostate Cancer.Semantic proximity Read ↗

Management of a Prostate Cancer Patient With Inherited Germline BRCA1 and BRCA2 Mutations: A Case Report.Semantic proximity Read ↗

Clinical features and management of BRCA1 and BRCA2-associated prostate cancer.Semantic proximity Read ↗

Prostate Cancer in a Patient with a Family History of BRCA Mutation: a Case Report and Literature Review.Semantic proximity Read ↗

Decreased prostate cancer-specific survival of men with BRCA2 mutations from multiple breast cancer families.Semantic proximity Read ↗

BRCA1 and BRCA2 have a limited role in familial prostate cancer.Semantic proximity Read ↗

Increased risk of male cancer and identification of a potential prostate cancer cluster region in BRCA2.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.