Article
Novel mitochondrial mutations in the ATP6 and ATP8 genes in patients with breast cancer.
Molecular medicine reports - 1 Oct 2014
Grzybowska-Szatkowska Ludmiła, Slaska Brygida, Rzymowska Jolanta, Brzozowska Anna, Floriańczyk Bolesław
Abstract excerpt
The role of the mitochondria in the process of carcinogenesis, mainly oxidative phosphorylation, mostly concerns their participation in the production of free radicals and ATP and in the process of apoptosis. The purpose of this study was to detect potential changes in the genes encoding the subunits 6 and 8 of the ATP synthase and their impact on the enzyme's biochemical properties, structure and function in...
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