Article
Genome-wide association study of sleep duration in the Finnish population.
Journal of sleep research - 1 Dec 2014
Ollila Hanna M, Kettunen Johannes, Pietiläinen Olli, Aho Vilma, Silander Kaisa, Kronholm Erkki, Perola Markus, Lahti Jari, Räikkönen Katri, Widen Elisabeth, Palotie Aarno, Eriksson Johan G, Partonen Timo, Kaprio Jaakko, Salomaa Veikko, Raitakari Olli, Lehtimäki Terho, Sallinen Mikael, Härmä Mikko, Porkka-Heiskanen Tarja, Paunio Tiina
Abstract excerpt
Sleep duration is genetically regulated, but the genetic variants are largely unknown. We aimed to identify such genes using a genome-wide association study (GWAS) combined with RNA expression at the population level, and with experimental verification. A GWAS was performed in a Finnish sample (n = 1941), and variants with suggestive association (P < 5 × 10(-5) ) were tested in a follow-up sample from the same...
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