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Article

Genetic architecture of sleep in a genome wide association study of device measured sleep traits.

Nature communications - 1 Apr 2026

Portas Laura, Yuan Hang, Cai Lina, Smith-Byrne Karl, van Duijvenboden Stefan, Kyle Simon D, Ray David, Howson Joanna Mm, Doherty Aiden

Abstract excerpt

Sleep is essential for health and regulated by genetic and environmental factors. We perform genome-wide association studies of device-measured sleep duration, efficiency, and accelerometer-derived rapid eye movement (REM) and non-rapid eye movement (NREM) sleep in 80,013 UK Biobank participants. We identify 20 autosomal loci, 12 of which have not been previously reported, including genome-wide significant...

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Identifiers

PMID: 41922918
DOI: 10.1038/s41467-026-71252-y
PMCID: PMC13212655

Genes

FOXP2
LRP1B
MEIS1
NPBWR2
NRXN3
PABPC4

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