Article
Evaluating the role of rare genetic variation in sleep duration.
Sleep health - 1 Oct 2022
Meng Peilin, Pan Chuyu, Cheng Shiqiang, Li Chun'e, Yao Yao, Liu Li, Cheng Bolun, Yang Xuena, Zhang Zhen, Chen Yujing, Zhang Jingxi, Zhang Huijie, Wen Yan, Jia Yumeng, Guo Xiong, Zhang Feng
Abstract excerpt
OBJECTIVES: To explore the roles of rare and high-impact variants in sleep duration. DESIGN: Based on the recently released UK Biobank 200k exome dataset, an exome-wide association study was conducted to detect rare variants (minor allele frequency <0.01) contributing to sleep duration. Variant annotations were performed by the software tool ANNOVAR. Gene-based burden tests of sleep duration were conducted by the...
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