Article
The impact of Mendelian sleep and circadian genetic variants in a population setting.
PLoS genetics - 1 Sept 2022
Weedon Michael N, Jones Samuel E, Lane Jacqueline M, Lee Jiwon, Ollila Hanna M, Dawes Amy, Tyrrell Jess, Beaumont Robin N, Partonen Timo, Merikanto Ilona, Rich Stephen S, Rotter Jerome I, Frayling Timothy M, Rutter Martin K, Redline Susan, Sofer Tamar, Saxena Richa, Wood Andrew R
Abstract excerpt
Rare variants in ten genes have been reported to cause Mendelian sleep conditions characterised by extreme sleep duration or timing. These include familial natural short sleep (ADRB1, DEC2/BHLHE41, GRM1 and NPSR1), advanced sleep phase (PER2, PER3, CRY2, CSNK1D and TIMELESS) and delayed sleep phase (CRY1). The association of variants in these genes with extreme sleep conditions were usually based on clinically...
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