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Article

Defects in dendrite and spine maturation and synaptogenesis associated with an anxious-depressive-like phenotype of GABAA receptor-deficient mice.

Neuropharmacology - 1 Jan 2015

Ren Zhen, Sahir Nadia, Murakami Shoko, Luellen Beth A, Earnheart John C, Lal Rachnanjali, Kim Ju Young, Song Hongjun, Luscher Bernhard

Abstract excerpt

Mice that were rendered heterozygous for the γ2 subunit of GABAA receptors (γ2(+/-) mice) have been characterized extensively as a model for major depressive disorder. The phenotype of these mice includes behavior indicative of heightened anxiety, despair, and anhedonia, as well as defects in hippocampus-dependent pattern separation, HPA axis hyperactivity and increased responsiveness to antidepressant drugs. The...

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Identifiers

PMID: 25107590
DOI: 10.1016/j.neuropharm.2014.07.019
PMCID: PMC4252742

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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