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Article

Claudin 4 knockout mice: normal physiological phenotype with increased susceptibility to lung injury.

American journal of physiology. Lung cellular and molecular physiology - 1 Oct 2014

Kage Hidenori, Flodby Per, Gao Danping, Kim Yong Ho, Marconett Crystal N, DeMaio Lucas, Kim Kwang-Jin, Crandall Edward D, Borok Zea

Abstract excerpt

Claudins are tight junction proteins that regulate paracellular ion permeability of epithelium and endothelium. Claudin 4 has been reported to function as a paracellular sodium barrier and is one of three major claudins expressed in lung alveolar epithelial cells (AEC). To directly assess the role of claudin 4 in regulation of alveolar epithelial barrier function and fluid homeostasis in vivo, we generated...

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Identifiers

PMID: 25106430
DOI: 10.1152/ajplung.00077.2014
PMCID: PMC4187039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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