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Claudin Heterogeneity and Control of Lung Tight Junctions

16 Oct 2012

Abstract excerpt

Lung epithelial cells interconnected by tight junctions provide a barrier to the free diffusion of solutes into airspaces. Transmembrane tight junction proteins known as claudins are essential for epithelial barrier function. Claudins are regulated through interactions with each other that are coordinated with other transmembrane tight junction proteins and cytosolic scaffold proteins. Of the 14 claudins...

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PMID: 23072447
DOI: 10.1146/annurev-physiol-030212-183809

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